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Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1961
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1961.tb01105.x